Advances in the Synthesis of Bioorthogonal Reagents: s-Tetrazines, 1, 2, 4-Triazines, Cyclooctynes, Heterocycloheptynes, and trans-Cyclooctenes

Y Fang, AS Hillman, JM Fox - Topics in Current Chemistry, 2024 - Springer
Aligned with the increasing importance of bioorthogonal chemistry has been an increasing
demand for more potent, affordable, multifunctional, and programmable bioorthogonal …

Heterocycloalkynes fused to a heterocyclic core: searching for an island with optimal stability-reactivity balance

NA Danilkina, AI Govdi, AF Khlebnikov… - Journal of the …, 2021 - ACS Publications
In the search for fundamentally new, active, stable, and readily synthetically accessible
cycloalkynes as strain-promoted azide–alkyne cycloaddition (SPAAC) reagents for …

Templated Generation of a Bcl‐xL Inhibitor by Isomer‐Free SPAAC Based on Azacyclonon‐5‐yne

J Brauer, M Mötzing, C Gröst… - … –A European Journal, 2022 - Wiley Online Library
High‐affinity inhibitors of large protein–protein interactions often have a high molecular
weight, which compromises their cell permeability and oral bioavailability. We recently …

Effect of Resonance on the Clickability of Alkenyl Azides in the Strain-promoted Cycloaddition with Dibenzo-fused Cyclooctynes

S Yoshida, S Goto, Y Nishiyama, Y Hazama… - Chemistry …, 2019 - academic.oup.com
The clickabilities of various alkenyl and alkyl azides in the strain-promoted cycloaddition
with dibenzo-fused cyclooctynes were investigated. Although alkenyl azides generally …

Five-membered ring systems: with more than one N atom

L Yet - Progress in Heterocyclic Chemistry, 2021 - Elsevier
Five-membered ring systems: with more than one N atom - ScienceDirect Skip to main
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Une nouvelle stratégie de développement de vaccins glycoconjugués

P Aubert - 2021 - hal.science
La production de molécules à haute valeur ajoutée à partir de ressources biologiques
implique souvent la transformation chimique des matières biosourcées, afin de permettre …