Urologic complications following pelvic radiotherapy

N Lobo, M Kulkarni, S Hughes, R Nair, MS Khan… - Urology, 2018 - Elsevier
Radiotherapy is widely used as a curative treatment for pelvic malignancies. The location of
these organs leads to unavoidable exposure of the bladder, urethra, and distal ureters to …

Modeling and treatment of radiation cystitis

BMM Zwaans, MB Chancellor, LE Lamb - Urology, 2016 - Elsevier
Radiation cystitis (RC) is a debilitating condition that, if not managed at an early stage, can
have a major impact on the quality of life of a patient and can lead to severe hemorrhaging …

[HTML][HTML] Urological complications after radiation therapy—nothing ventured, nothing gained: a Narrative Review

J Chorbińska, W Krajewski… - Translational Cancer …, 2021 - ncbi.nlm.nih.gov
Radiation therapy along with chemotherapy and surgery are the three main treatment
modalities used in oncology. The main disadvantage of radiotherapy is the fact that it affects …

Molecular mechanisms and key processes in interstitial, hemorrhagic and radiation cystitis

C Brossard, AC Lefranc, AL Pouliet, JM Simon… - Biology, 2022 - mdpi.com
Simple Summary Pathologies of the bladder are called cystitis. They cause discomfort for the
patient. Due to persistent pain, bleeding, urinary incontinence, and uncontrolled urination …

Increased extracellular matrix stiffness accompanies compromised bladder function in a murine model of radiation cystitis

BMM Zwaans, M Grobbel, AL Carabulea, LE Lamb… - Acta biomaterialia, 2022 - Elsevier
Radiation cystitis, a long-term bladder defect due to pelvic radiation therapy, results in lower
urinary tract symptoms, such as urinary frequency and nocturia, suggestive of compromised …

Precise image-guided irradiation of small animals: a flexible non-profit platform

F Tillner, P Thute, S Löck, A Dietrich… - Physics in Medicine …, 2016 - iopscience.iop.org
Preclinical in vivo studies using small animals are essential to develop new therapeutic
options in radiation oncology. Of particular interest are orthotopic tumour models, which …

Biomaterial-assisted drug delivery for interstitial cystitis/bladder pain syndrome treatment

Z Lin, H Hu, B Liu, Y Chen, Y Tao, X Zhou… - Journal of Materials …, 2021 - pubs.rsc.org
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and painful bladder condition
afflicting patients with increased urinary urgency and frequency as well as incontinence …

Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options

A Ganguly, S Tyagi, C Chermansky, A Kanai, J Beckel… - Drugs & aging, 2023 - Springer
This article provides an overview of the diagnosis and the treatment of lower urinary tract
symptoms in older adults complicated by the neurodegenerative changes in the micturition …

[HTML][HTML] Challenges and opportunities in radiation-induced hemorrhagic cystitis

BMM Zwaans, HG Nicolai, MB Chancellor… - Reviews in …, 2016 - ncbi.nlm.nih.gov
As diagnosis and treatment of cancer is improving, medical and social issues related to
cancer survivorship are becoming more prevalent. Hemorrhagic cystitis (HC), a rare but …

Intravesical liposomal tacrolimus for hemorrhagic cystitis: A phase 2a multicenter dose-escalation study

J Hafron, BN Breyer, S Joshi, C Smith… - … Urology and Nephrology, 2024 - Springer
Background Hemorrhagic cystitis (HC) is an inflammatory disease of the bladder with
sustained hematuria for which there is currently no approved drug treatment. We evaluated …