Pyrido [2, 3-d] pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of
providing ligands for several receptors in the body. Among such structures, our group and …

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm with a heterogeneous clinical and
biological behavior. SOX11 oncogenic expression contributes to the aggressiveness of …

Targeting the kinases MNK1 and MNK2 has emerged as a valuable strategy in oncology.
However, most of the advanced inhibitors are acting in an adenosine triphosphate (ATP) …

Background Immunotherapy-based regimens have considerably improved the survival rate
of B-cell non-Hodgkin lymphoma (B-NHL) patients in the last decades; however, most …

Purpose: Despite the remarkable activity of BTK inhibitors (BTKi) in relapsed B-cell non–
Hodgkin lymphoma (B-NHL), no clinically-relevant biomarker has been associated to these …

Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor
progression, invasion, and chemotherapy resistance in different cancer subtypes. Although …

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in adults,
characterized by a rapidly increasing painless mass. A novel compound, DCZ3301, was …

Toll‐like receptors (TLRs) sense the presence of pathogen‐associated molecular patterns.
Nevertheless, the mechanisms modulating TLR‐triggered innate immune responses are not …

Spleen tyrosine kinase (SYK) and Bruton's tyrosine kinase (BTK) are attractive targets in
human haematological malignancies with excessively activated B-cell receptor (BCR) …

Mantle cell lymphoma (MCL) is a comparatively rare non-Hodgkin's lymphoma
characterised by overexpression of cyclin D1. Many patients present with or progress to …