Efficient movement of proteins across membranes is required for cell health. The
translocation process is particularly challenging when the channel in the membrane through …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

In eukaryotes, up to one-third of cellular proteins are targeted to the endoplasmic reticulum,
where they undergo folding, processing, sorting and trafficking to subsequent …

The evolutionary emergence of organelles was a defining process in diversifying
biochemical reactions within the cell and enabling multicellularity. However …

Cellular functions are dictated by protein content and activity. There are numerous strategies
to regulate proteins varying from modulating gene expression to post‐translational …

Members of the evolutionarily conserved Oxa1/Alb3/YidC family mediate membrane protein
biogenesis at the mitochondrial inner membrane, chloroplast thylakoid membrane, and …

Yeasts and especially Pichia pastoris (syn Komagataella spp.) are popular microbial
expression systems for the production of recombinant proteins. One of the key advantages of …

The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells, responsible for
protein synthesis, folding, sorting, and transportation. ER stress is initiated when the …

Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the
heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC systems and …

Translocation into the endoplasmic reticulum (ER) is the first step in the biogenesis of
thousands of eukaryotic endomembrane proteins. Although functional ER translocation has …