[HTML][HTML] Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD). Mitochondria as players and targets of therapies?
A Di Ciaula, S Passarella, H Shanmugam… - International Journal of …, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …
[HTML][HTML] A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria …
The present review is a sequel to the previous review on cancer metabolism published in
this journal. This review focuses on the selective antiproliferative and cytotoxic effects of …
this journal. This review focuses on the selective antiproliferative and cytotoxic effects of …
Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications
N Apostolova, VM Victor - Antioxidants & redox signaling, 2015 - liebertpub.com
Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …
fundamental in controlling the life and death of cells, and has been implicated in a wide …
Targeting antioxidants to mitochondria by conjugation to lipophilic cations
Mitochondrial oxidative damage contributes to a range of degenerative diseases.
Consequently, the selective inhibition of mitochondrial oxidative damage is a promising …
Consequently, the selective inhibition of mitochondrial oxidative damage is a promising …
Animal and human studies with the mitochondria‐targeted antioxidant MitoQ
As mitochondrial oxidative damage contributes to a wide range of human diseases,
antioxidants designed to be accumulated by mitochondria in vivo have been developed. The …
antioxidants designed to be accumulated by mitochondria in vivo have been developed. The …
[HTML][HTML] Structural features of small molecule antioxidants and strategic modifications to improve potential bioactivity
This review surveys the major structural features in various groups of small molecules that
are considered to be antioxidants, including natural and synthetic compounds alike. Recent …
are considered to be antioxidants, including natural and synthetic compounds alike. Recent …
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease
MJ McManus, MP Murphy, JL Franklin - Journal of Neuroscience, 2011 - Soc Neuroscience
Considerable evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the progression of Alzheimer's disease (AD). We examined the ability of the …
contribute to the progression of Alzheimer's disease (AD). We examined the ability of the …
Mitochondria-targeted small molecule therapeutics and probes
Significance: Mitochondrial function is central to a wide range of biological processes in
health and disease and there is considerable interest in developing small molecules that are …
health and disease and there is considerable interest in developing small molecules that are …