While high doses of estrogen, in combination with androgens, can initiate prostate cancer
(PCa) via activation of the estrogen receptor α (ERα), the role of ERα in PCa cells within …

Background: Recently there has been an increased interest in the role of tumor-associated
stroma in prostate tumorigenesis, but little is known about the respective roles of stomal ERα …

BACKGROUND Carboxypeptidase‐D (CPD) cleaves C‐terminal arginine for conversion to
nitric oxide (NO) by nitric oxide synthase (NOS). Prolactin (PRL) and androgens stimulate …

BACKGROUND Estrogens acting through the receptors ERα and ERβ participate in prostate
normal growth and cancer. ERβ is highly expressed in the prostate epithelium, playing pro …

Cancers are heterogeneous multifactorial diseases consisting of a major public health issue
worldwide. Sex disparities are evidenced in cancer incidence, mortality, expression of …

Although the prostate is androgen-dependent, it is also influenced by estrogens, which act
via the estrogen receptors ERα and ERβ. In the prostate, ERβ is highly expressed in the …

BACKGROUND Carboxypeptidase‐D (CPD) cleaves C‐terminal arginine for nitric oxide
(NO) production. CPD and NO levels are upregulated by testosterone (T) and prolactin …

The aim was to characterize and correlate steroid hormone receptors with the FGF2, FGF7
and FGF8 reactivities in the prostatic epithelium and stroma in senile rats. Fifty male senile …

The recent developments in anti-angiogenic and immunomodulatory drugs show that the
tumour micro-environment (TME) becomes increasingly important in cancer research. Here …

A major clinical challenge is posed by the current inability to readily distinguish indolent from
aggressive tumors in prostate cancer patients. Research efforts are dedicated to overcome …