Traumatic injuries can lead to large bone defects under extreme conditions, which usually
take a long recovery period, while the prognosis is poor. Endogenous electric field, as one …

Calcium phosphate ceramics (CPCs) have been widely used as biomaterials for the
regeneration of bone tissue because of their ability to induce osteoblastic differentiation in …

Mechanical load of the skeleton system is essential for the development, growth, and
maintenance of bone. However, the molecular mechanism by which mechanical stimuli are …

The discovery of osteoinductivity of calcium phosphate (Ca-P) ceramics has set an enduring
paradigm of conferring biological regenerative activity to materials with carefully designed …

The skeleton provides mechanical support for stature and locomotion, protects vital organs,
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …

Ca2+ is a ubiquitous intracellular messenger responsible for controlling numerous cellular
processes including fertilization, mitosis, neuronal transmission, contraction and relaxation …

Large segmental bone loss and bone resection due to trauma and/or the presence of tumors
and cysts often results in a delay in healing or non-union. Currently, the bone autograft is the …

Abstract Calcium (Ca2+) signaling is essential for a variety of cellular responses and higher
biological functions. Ca2+/calmodulin-dependent kinases (CaMKs) and the phosphatase …

Hydrogels composed from biomolecules have gained great interests as biomaterials for
tissue engineering. However, their poor mechanical properties limit their application …

The pannexin proteins represent a new gap junction family. However, the cellular functions
of pannexins remain largely unknown. Here, we demonstrate that pannexin 3 (Panx3) …