Local anesthetic systemic toxicity (LAST) is a life-threatening adverse event that may occur
after the administration of local anesthetic drugs through a variety of routes. Increasing use …

Abstract The American Society of Regional Anesthesia and Pain Medicine's Third Practice
Advisory on local anesthetic systemic toxicity is an interim update from its 2010 advisory …

Background Weinberg et al. 1 first showed in 1998 that an infusion of a soybean oil
emulsion normally used as a total parenteral nutrition solution could prevent (by …

Introduction Emergency clinicians utilize local anesthetics for a variety of procedures in the
emergency department (ED) setting. Local anesthetic systemic toxicity (LAST) is a potentially …

The experimental use of lipid emulsion for local anesthetic toxicity was originally identified in
1998. It was then translated to clinical practice in 2006 and expanded to drugs other than …

Lipid emulsion has been shown to be an effective treatment for systemic toxicity induced by
local anesthetics, which is reflected in case reports. A systemic review and meta-analysis …

Abstract Purpose of Review Myocardial metabolism is intricately linked to cardiac function.
Perturbations of cardiac energy metabolism result in an energy-starved heart and the …

Currently, lipid emulsion (LE) is widely used to treat local anesthetic systemic toxicity (LAST).
LE also ameliorates intractable cardiovascular collapse caused by lipid-soluble non-local …

Background and Purpose Recent evidence indicates that GPER (G protein‐coupled
oestrogen receptor 1) mediates acute pre‐ischaemic oestrogen‐induced protection of the …

Objectives: Bolus infusion of lipid emulsion can reverse cardiac pharmacotoxicity caused by
local anesthetics and other lipophilic drugs. The mechanisms of this effect are not …