The recommendations that follow have been updated from the proposals of a Technical
Subcommittee set up by the International Union of Pharmacology Committee on Receptor …

α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake
venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic'neurotoxins, they …

The concept of ligand bias at G protein-coupled receptors broadens the possibilities for
agonist activities and provides the opportunity to develop safer, more selective therapeutics …

Biased G protein-coupled receptor ligands engage subsets of the receptor signals normally
stimulated by unbiased agonists. However, it is unclear whether ligand bias can elicit …

The role of transporters in clearing free glutamate from the synaptic cleft was studied in rat
CA1 hippocampal neurons cultured on glial microislands. The time course of free glutamate …

In the accompanying report (Wypych, J., Li, M., Guo, A., Zhang, Z., Martinez, T., Allen, MJ,
Fodor, S., Kelner, DN, Flynn, GC, Liu, YD, Bondarenko, PV, Ricci, MS, Dillon, TM, and …

Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cell
and tissue responses via a set of cell surface receptors. The recent development of S1P …

Most natural odors are complex mixtures of volatile components, competing to bind odorant
receptors (ORs) expressed in olfactory sensory neurons (OSNs) of the nose. To date …

Many persistent organochlorine pesticides (OCs) have been implicated in adverse effects,
that is, reproductive and developmental effects, in man and in wildlife alike. It has been …

BACKGROUND AND PURPOSE Studies of the role of the prostaglandin EP2 receptor) have
been limited by the availability of potent and selective antagonist tools. Here we describe the …