Drug repurposing strategies in the development of potential antifungal agents
Q Zhang, F Liu, M Zeng, Y Mao, Z Song - Applied Microbiology and …, 2021 - Springer
The morbidity and mortality caused by invasive fungal infections are increasing across the
globe due to developments in transplant surgery, the use of immunosuppressive agents …
globe due to developments in transplant surgery, the use of immunosuppressive agents …
Augmenting azoles with drug synergy to expand the antifungal toolbox
Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …
Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent
S Thangamani, H Mohammad, MFN Abushahba… - Scientific reports, 2015 - nature.com
The rapid rise of bacterial resistance to traditional antibiotics combined with the decline in
discovery of novel antibacterial agents has created a global public health crisis …
discovery of novel antibacterial agents has created a global public health crisis …
Farnesol signalling in Candida albicans – more than just communication
M Polke, I Leonhardt, O Kurzai… - Critical Reviews in …, 2018 - Taylor & Francis
Candida albicans is a successful colonizer of the human host, which can, under certain
circumstances cause a range of clinically diverse infections. Important virulence-associated …
circumstances cause a range of clinically diverse infections. Important virulence-associated …
Antifungal effects of statins
Fungal infections are estimated to be responsible for 1.5 million deaths annually. Global anti-
microbial resistance is also observed for fungal pathogens, and scientists are looking for …
microbial resistance is also observed for fungal pathogens, and scientists are looking for …
Lovastatin production by an oleaginous fungus, Aspergillus terreus KPR12 using sago processing wastewater (SWW)
N Srinivasan, K Thangavelu, S Uthandi - Microbial Cell Factories, 2022 - Springer
Background Lovastatin is one of the first statins to be extensively used for its cholesterol-
lowering ability. It is commercially produced by fermentation. Species belonging to the …
lowering ability. It is commercially produced by fermentation. Species belonging to the …
Exploitation of Aspergillus terreus for the Production of Natural Statins
The fungus Aspergillus (A.) terreus has dominated the biological production of the
“blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA …
“blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA …
[HTML][HTML] Are the Statins promising antifungal agents against invasive candidiasis?
WG Lima, LA Alves-Nascimento, JT Andrade… - Biomedicine & …, 2019 - Elsevier
The medical importance of intra-abdominal candidiasis (IAC) contrasts with the limited
number of pharmacological treatment options available and the increasing rate of resistance …
number of pharmacological treatment options available and the increasing rate of resistance …
Systematic review of the in vitro effects of statins on oral and perioral microorganisms
M Ting, EJ Whitaker… - European Journal of Oral …, 2016 - Wiley Online Library
Statins are medications administered orally and are widely used for lowering the blood
cholesterol level. The aim of this study was to investigate the effects of orally administered …
cholesterol level. The aim of this study was to investigate the effects of orally administered …
Atorvastatin as a promising anticryptococcal agent
N de Queiroz Ribeiro, MC Costa… - International journal of …, 2017 - Elsevier
Cryptococcosis caused by Cryptococcus gattii leads to pneumonia and
meningoencephalitis, and has a high mortality rate worldwide due to the inadequacy of …
meningoencephalitis, and has a high mortality rate worldwide due to the inadequacy of …