In concert with neuropeptides and transmitters, the end products of the hypothalamus-
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …

Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

In the forced swim test (FST) rodents progressively show increased episodes of immobility if
immersed in a beaker with water from where escape is not possible. In this test, a compound …

Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …

Two receptor systems for corticosterone (CORT) can be distinguished in rat brain:
mineralocorticoidlike or CORT receptors (CR) and glucocorticoid receptors (GR). The …

Brain Corticosteroid Receptor Balance in Health and Disease* | Endocrine Reviews | Oxford
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In this review, we report on studies that have assessed the effects of exogenous and
endogenous increases in stress hormones on human cognitive performance. We first …

Cognitive deficits following acute administration of corticosteroids have been described in
experimental animals and humans. In both populations, an inverted-U shape relationship …

Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several
diseases in consideration of both anti-inflammatory and immunosuppressive activity but, if …

Glucocorticoid secretion is tightly regulated by negative feedback. Glucocorticoid feedback
has been found to be altered in depression and post-traumatic stress disorder (PTSD). While …