Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with
parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle …

The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses
eight functional members in humans. The proteins are secreted by diverse innate immune …

Helminth parasites are masters at manipulating host immune responses, using an array of
sophisticated mechanisms. One of the major mechanisms enabling helminths to establish …

CRISPR/Cas9-based genome editing has yet to be reported in species of the
Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma …

Helminth infections represent a significant public health concern resulting in devastating
morbidity and economic consequences across the globe. Helminths migrate through …

Schistosomes are long lived, intravascular parasitic platyhelminths that infect> 200 million
people globally. The molecular mechanisms used by these blood flukes to dampen host …

The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2)
responses, including those elicited by parasitic helminths, remain incompletely understood …

Parasitic worms (helminths) developed various immunoregulatory mechanisms to
counteract the immune system of their host. The increasing identification and …

The morbidity associated with atopic diseases and immune dysregulation disorders such as
asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and …