The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin
family of calcium-activated chloride channels with diverse cellular functions. ANO1 controls …

Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the
population but its aetiology, including suspected genetic predisposition, is poorly …

Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to
generate rhythmic bursts of action potential. Recent work has identified rhythmic gut …

The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in
development and disease; however, the mechanisms underlying their interplay remain …

Animals have evolved within the framework of microbes and are constantly exposed to
diverse microbiota. Microbes colonize most, if not all, animal epithelia and influence the …

The TMEM16A channel, a member of the TMEM16 protein family comprising chloride (Cl−)
channels and lipid scramblases, is activated by the free intracellular Ca 2+ increments …

Transmembrane protein family members (TMEMs) span the entire lipid bilayer and act as
channels that allow the transport of specific substances through biofilms. The functions of …

According to the Greek mythology (1), Heracles' second labor was the destruction of the
Lernaean Hydra, a fearsome fire-breathing monster with a dog-like body and nine snake …

The Sonic Hedgehog (Shh) signalling pathway plays multiple roles during embryonic
development and under pathological conditions. Although the core components of the Shh …