Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Sex differences in biological aging with a focus on human studies

S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Gender inequality and restrictive gender norms: framing the challenges to health

L Heise, ME Greene, N Opper, M Stavropoulou… - The Lancet, 2019 - thelancet.com
Gender is not accurately captured by the traditional male and female dichotomy of sex.
Instead, it is a complex social system that structures the life experience of all human beings …

Menopause: a cardiometabolic transition

RE Nappi, P Chedraui, I Lambrinoudaki… - The Lancet Diabetes & …, 2022 - thelancet.com
Menopause is often a turning point for women's health worldwide. Increasing knowledge
from experimental data and clinical studies indicates that cardiometabolic changes can …

Sex as a biological variable in atherosclerosis

JJ Man, JA Beckman, IZ Jaffe - Circulation research, 2020 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory vascular disease and the predominant cause of
heart attack and ischemic stroke. Despite the well-known sexual dimorphism in the …

Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease

W Wang, M Hu, H Liu, X Zhang, H Li, F Zhou, YM Liu… - Cell metabolism, 2021 - cell.com
Metabolic dysfunction is becoming a predominant risk for the development of many
comorbidities. Ischemic heart disease (IHD) still imposes the highest disease burden among …

[HTML][HTML] Improving the enrollment of women and racially/ethnically diverse populations in cardiovascular clinical trials: an ASPC practice statement

ED Michos, TK Reddy, M Gulati, LPC Brewer… - American Journal of …, 2021 - Elsevier
Cardiovascular disease (CVD) remains the leading cause of death for both women and men
worldwide. In the United States (US), there are significant disparities in cardiovascular risk …

Coronary arterial function and disease in women with no obstructive coronary arteries

HR Reynolds, CN Bairey Merz, C Berry… - Circulation …, 2022 - Am Heart Assoc
Ischemic heart disease (IHD) is the leading cause of mortality in women. While traditional
cardiovascular risk factors play an important role in the development of IHD in women …

Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care

GF Watts, SS Gidding, P Mata, J Pang… - Nature Reviews …, 2020 - nature.com
Optimal care for familial hypercholesterolaemia (FH) requires patient-centred management,
multidisciplinary teamwork, involvement of primary care practitioners, patient networks …

PET/MR imaging of inflammation in atherosclerosis

ML Senders, C Calcagno, A Tawakol… - Nature Biomedical …, 2023 - nature.com
Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune
diseases, cancer and the human immunodeficiency virus impact the haematopoietic system …