Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
[HTML][HTML] Multiclonal tumor origin: Evidence and implications
BL Parsons - Mutation research/reviews in mutation research, 2018 - Elsevier
An accurate understanding of the clonal origins of tumors is critical for designing effective
strategies to treat or prevent cancer and for guiding the field of cancer risk assessment. The …
strategies to treat or prevent cancer and for guiding the field of cancer risk assessment. The …
RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade
MJ Nokin, A Mira, E Patrucco, B Ricciuti… - Nature …, 2024 - nature.com
Selective KRASG12C inhibitors have been developed to covalently lock the oncogene in the
inactive GDP-bound state. Two of these molecules, sotorasib and adagrasib, are approved …
inactive GDP-bound state. Two of these molecules, sotorasib and adagrasib, are approved …
FOXA1 regulates alternative splicing in prostate cancer
Dysregulation of alternative splicing in prostate cancer is linked to transcriptional programs
activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1 functions as the …
activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1 functions as the …
Bioinformatics identification of TUBB as potential prognostic biomarker for worse prognosis in ERα-positive and better prognosis in ERα-negative breast cancer
R Alhammad - Diagnostics, 2022 - mdpi.com
Tubulin β class I gene (TUBB) is highly expressed in various cancers and plays several
roles in carcinogenesis. However, the prognostic value of TUBB in breast cancer remains to …
roles in carcinogenesis. However, the prognostic value of TUBB in breast cancer remains to …
Collision of germline POLE and PMS2 variants in a young patient treated with immune checkpoint inhibitors
E Berrino, R Filippi, C Visintin, S Peirone… - NPJ Precision …, 2022 - nature.com
The onset of multiple and metachronous tumors in young patients induces to suspect the
presence of genetic variants in genes associated with tumorigenesis. We describe here the …
presence of genetic variants in genes associated with tumorigenesis. We describe here the …
Microsatellite instability and immune response: from microenvironment features to therapeutic actionability—lessons from colorectal cancer
L Greco, F Rubbino, A Dal Buono, L Laghi - Genes, 2023 - mdpi.com
Microsatellite instability (MSI) can be found in 15–20% of all colorectal cancers (CRC) and is
the key feature of a defective DNA mismatch repair (MMR) system. Currently, MSI has been …
the key feature of a defective DNA mismatch repair (MMR) system. Currently, MSI has been …
Evolving notions on immune response in colorectal cancer and their implications for biomarker development
F Grizzi, G Basso, EM Borroni, T Cavalleri… - Inflammation …, 2018 - Springer
Introduction Colorectal cancer (CRC) still represents the third most commonly diagnosed
type of cancer in men and women worldwide. CRC is acknowledged as a heterogeneous …
type of cancer in men and women worldwide. CRC is acknowledged as a heterogeneous …
[HTML][HTML] Alternative tissue fixation protocols dramatically reduce the impact of DNA artifacts, unraveling the interpretation of clinical comprehensive genomic profiling
E Berrino, SE Bellomo, A Chesta, P Detillo… - Laboratory …, 2024 - Elsevier
Formalin-fixed paraffin-embedded (FFPE) samples represent the cornerstone of tissue-
based analysis in precision medicine. Targeted next-generation sequencing panels are …
based analysis in precision medicine. Targeted next-generation sequencing panels are …
Uncovering potential genes in colorectal cancer based on integrated and DNA methylation analysis in the gene expression omnibus database
G Wang, F Wang, Z Meng, N Wang, C Zhou, J Zhang… - BMC cancer, 2022 - Springer
Background Colorectal cancer (CRC) is major cancer-related death. The aim of this study
was to identify differentially expressed and differentially methylated genes, contributing to …
was to identify differentially expressed and differentially methylated genes, contributing to …