Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
The multi-step degradation process of PROteolysis TArgeting Chimeras (PROTACs) poses a
challenge for their rational development, as the rate-limiting steps that determine PROTACs …
challenge for their rational development, as the rate-limiting steps that determine PROTACs …
Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional
units of the kidney. Here, manipulation of p38 and YAP activity allowed for long-term clonal …
units of the kidney. Here, manipulation of p38 and YAP activity allowed for long-term clonal …
Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings
M Schröder, M Renatus, X Liang, F Meili, T Zoller… - BioRxiv, 2023 - biorxiv.org
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras
(PROTACs) or molecular glues has emerged as a key modality in exploring new biology as …
(PROTACs) or molecular glues has emerged as a key modality in exploring new biology as …
Targeting Epigenetic Readers Using Small Molecule Binders and PROTAC Degraders
E Boccia, E Gazzillo, MG Chini, G Bifulco, G Lauro - 2024 - Springer
The word epigenetics originated from Greek ἐπί, epì,“above,” and γεννητικός,
gennetikòs,“relating to family inheritance,” literally above the genome. This term was first …
gennetikòs,“relating to family inheritance,” literally above the genome. This term was first …
WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
WL Cai, JF Chen, H Chen, E Wingrove, SJ Kurley… - bioRxiv, 2022 - biorxiv.org
Metastatic breast cancer remains a major cause of cancer related deaths in women and
there are few effective therapies against this advanced disease. Emerging evidence …
there are few effective therapies against this advanced disease. Emerging evidence …