At first glance the nucleus is a highly conserved organelle. Overall nuclear morphology, the
octagonal nuclear pore complex, the presence of peripheral heterochromatin and the …

Protozoan parasites continue to cause a significant health and economic burden worldwide.
As infectious organisms, they pose unique and difficult challenges due to a level of …

Lysine lactylation has been recognized as a novel post-translational modification occurring
on histones. However, lactylation in non-histone proteins, especially in proteins of early …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

Background The protozoan malaria parasite Plasmodium falciparum has a complex life
cycle during which it needs to differentiate into multiple morphologically distinct life forms. A …

Nucleosomes composed of histones are the fundamental units around which DNA is
wrapped to form chromatin. Transcriptionally active euchromatin or repressive …

Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually
associated with adaptation to stress conditions. Chromosomal duplication stability is a …

Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and
display some unusual genomic and epigenetic properties that provide valuable insight into …

Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

In higher eukaryotes, a single DOT1 histone H3 lysine 79 (H3K79) methyltransferase
processively produces H3K79me2/me3 through histone H2B mono-ubiquitin interaction …