Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Extracellular matrix (ECM) molecules are responsible for structural and biochemical support,
as well as for regulation of molecular signalling and tissue repair in many organ structures …

The interaction between the immune system and endocrine cells in the pancreas is crucial
for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

The extracellular matrix (ECM) comes in different structural forms and biochemical
compositions, which determine both its biophysical properties and its ability to convey …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which autoreactive T‐cells and
inflammation cause severe loss of pancreatic beta cells. Insulitis, the pathologic hallmark of …

Type 1 diabetes is increasing in incidence in many parts of the world and it might be
imagined that the pathological processes that underlie disease progression are firmly …