It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …

Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

Accumulation of tau has been implicated in various neurodegenerative diseases termed
tauopathies. Tau is a microtubule-associated protein but is also actively released into the …

Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

Alzheimer's disease (AD) causes unrelenting, progressive cognitive impairments, but its
course is heterogeneous, with a broad range of rates of cognitive decline. The spread of tau …

Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of
β-amyloid (Aβ) that accumulates in Alzheimer's disease (AD). Furthermore, chronic sleep …

APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases
brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE …

We developed stable isotope labeling and mass spectrometry approaches to measure the
kinetics of multiple isoforms and fragments of tau in the human central nervous system …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …