Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disorder
associated with polycystic liver disease (PLD) and other extrarenal manifestations, the most …

The alteration of water balance and related disorders has emerged as being strictly linked to
the state of activation of the vasopressin–aquaporin-2 (vasopressin–AQP2) pathway. The …

This review focuses on the most recent advances in the understanding of the electrolyte
transport-related mechanisms important for the development of severe inherited renal …

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations of PKD1 or
PKD2 genes, is characterized by development and growth of cysts causing progressive …

Abstract Polycystin-2 (TRPP2, PKD2, PC2) is the product of the PKD2 gene, whose
mutations cause Autosomal Dominant Polycystic Kidney Disease (ADPKD). PC2 belongs to …

Calcium (Ca2+) is a universal and vital intracellular messenger involved in a diverse range
of cellular and biological processes. Changes in the concentration of extracellular Ca2+ can …

There is evidence that ATM mutated in ataxia-telangiectasia (AT) plays a key role in
protecting against mitochondrial dysfunction, the mechanism for which remains unresolved …

Cardiac hypertrophy is common in autosomal dominant polycystic kidney disease (ADPKD)
patients. We found increased heart weight in Pkd1 RC/RC and Pkd2 WS25/+ mouse models …

Vasopressin is the key hormone involved in water conservation and regulation of water
balance, essential for life. In the renal collecting duct, vasopressin binds to the V2 receptor …

The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-
surface-located receptor that can induce highly diffusible messengers (IP3, Ca2+, cAMP) in …