Molecular mechanisms of anticancer effect of rutin

A Imani, N Maleki, S Bohlouli… - Phytotherapy …, 2021 - Wiley Online Library
Because of the extensive biological functions of natural substances such as bioflavonoids,
and their high safety and low costs, they could have high priority application in the health …

Polyphenols in metabolic diseases

A Gasmi, PK Mujawdiya, S Noor, R Lysiuk… - Molecules, 2022 - mdpi.com
Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or
more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic …

Nanoemulsions for “nose-to-brain” drug delivery

MC Bonferoni, S Rossi, G Sandri, F Ferrari, E Gavini… - Pharmaceutics, 2019 - mdpi.com
The blood–brain barrier (BBB) plays a fundamental role in protecting the brain from toxic
substances and therefore also controls and restricts the entry of therapeutic agents. The …

Nanodelivery of natural antioxidants: an anti-aging perspective

A Vaiserman, A Koliada, A Zayachkivska… - … in bioengineering and …, 2020 - frontiersin.org
The aging process is known to be associated with heightened oxidative stress and related
systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising …

Oxidative and nitrative stress in neurodegeneration

CA Cobb, MP Cole - Neurobiology of disease, 2015 - Elsevier
Aerobes require oxygen for metabolism and normal free radical formation. As a result,
maintaining the redox homeostasis is essential for brain cell survival due to their high …

Intranasal nanoemulsions for direct nose-to-brain delivery of actives for CNS disorders

S Bahadur, DM Pardhi, J Rautio, JM Rosenholm… - Pharmaceutics, 2020 - mdpi.com
The treatment of various central nervous system (CNS) diseases has been challenging,
despite the rapid development of several novel treatment approaches. The blood–brain …

Formulation, characterization, and evaluation of β-Cyclodextrin functionalized hypericin loaded nanocarriers

MA Waqar, M Zaman, H Hameed, M Jamshaid… - ACS …, 2023 - ACS Publications
St. John's wort in western Europe has been extensively utilized for the treatment of mild to
moderate depression. Hypericin, a red pigment, is found to be responsible for its …

Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies

PC Pires, AO Santos - Journal of controlled release, 2018 - Elsevier
The treatment of neurodegenerative and psychiatric disorders remains a challenge in
medical research. Several strategies have been developed over the years, either to …

Nanoformulations of herbal extracts in treatment of neurodegenerative disorders

SZ Moradi, S Momtaz, Z Bayrami… - … in bioengineering and …, 2020 - frontiersin.org
Nanotechnology is one of the methods that influenced human life in different ways and is a
substantial approach that assists to overcome the multiple limitations of various diseases …

Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents

A Angelova, VM Garamus, B Angelov, Z Tian… - Advances in colloid and …, 2017 - Elsevier
The present work highlights recent achievements in development of nanostructured
dispersions and biocolloids for drug delivery applications. We emphasize the key role of …