Introduction The dysregulation of CDK9 protein is greatly related to the proliferation and
differentiation of various cancers due to its key role in the regulation of RNA transcription …

Accumulating evidence has indicated that mRNA splicing plays critical roles in a variety of
physiological processes, including development of multiple diseases. In particular …

Simple Summary Primary concurrent platinum-based chemoradiation (CRT) is the standard-
of-care treatment for locally advanced cervical cancer. However, persistent, recurrent or …

Background Bladder cancer (BLCA) is the ninth most common cancer globally, as well as
the fourth most common cancer in men, with an incidence of 7%. However, few effective …

Abstract α-Enolase (ENO1) is a crucial molecular target for tumor therapy and has emerged
as a research hotspot in recent decades. Here, we aimed to explore the role of ENO1 in …

Abstract Objectives Pyroptosis-related genes (PRGs) are abnormally expressed in a variety
of gastrointestinal tumors, this study aimed to investigate the role of pyroptosis genes in …

Purpose The mutation of p53 is considered a pivotal step in bladder cancer pathogenesis.
Recently, distinct interactions between p53 and CDK9, a transcription regulator, have been …

Cyclin-dependent kinases (CDK) are key regulators of the transcriptional cycle, and they are
often deregulated in cancer cells. Together with the transcriptional addiction of tumours, this …