IL-10 is a cytokine with pleiotropic functions, particularly known for its suppressive effects on
various immune cells. Consequently, it can limit the pathogenesis of inflammatory diseases …

T helper cells aid B cells with the production of antibodies and thus play a central role in
disease development of systemic lupus erythematosus (SLE). Numerous T helper cell …

Malaria, which results from infection with Plasmodium parasites, remains a major public
health problem. Although humans do not develop long-lived, sterilizing immunity, protection …

Production of IFN-γ by CD4 T cells is widely theorized to control Plasmodium parasite
burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms …

The pathogenic role B cells play in multiple sclerosis is underscored by the success of B cell
depletion therapies. Yet, it remains unclear how B cells contribute to disease, although it is …

Malaria comprises a spectrum of disease syndromes and the immune system is a major
participant in malarial disease. This is particularly true in relation to the immune responses …

The cytokine IL-10 suppresses T-cell-mediated immunity, which is required to control
infection with Plasmodium yoelii. Consequently, IL-10 can delay the time needed to resolve …

Urinary tract infections (UTIs) represent a clinical and epidemiological problem of worldwide
impact that affects the economy and the emotional state of the patient. Control of the …

While tumor-associated macrophages (TAM) have pro-tumoral activity, the ablation of
macrophages in cancer may be undesirable since they also have anti-tumoral functions …

Malaria is strongly predisposed to bacteremia, which is associated with increased
gastrointestinal permeability and a poor clinical prognosis. We previously identified mast …