Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
COVID-19: ICU delirium management during SARS-CoV-2 pandemic
The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19),
emerged as a public health threat in December 2019 and was declared a pandemic by the …
emerged as a public health threat in December 2019 and was declared a pandemic by the …
Mitophagy and Alzheimer's disease: cellular and molecular mechanisms
JS Kerr, BA Adriaanse, NH Greig, MP Mattson… - Trends in …, 2017 - cell.com
Neurons affected in Alzheimer's disease (AD) experience mitochondrial dysfunction and a
bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta …
bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta …
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Emerging findings suggest that compromised cellular bioenergetics and DNA repair
contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining …
contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining …
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
A nuclease that mediates cell death induced by DNA damage and poly (ADP-ribose) polymerase-1
Y Wang, R An, GK Umanah, H Park, K Nambiar… - Science, 2016 - science.org
INTRODUCTION Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) is a nuclear enzyme
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …
PARP-1 and its associated nucleases in DNA damage response
Abstract Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
Multifaceted role of PARP-1 in DNA repair and inflammation: pathological and therapeutic implications in cancer and non-cancer diseases
S Pazzaglia, C Pioli - Cells, 2019 - mdpi.com
PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic
fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS. Proper shuttling …
fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS. Proper shuttling …