The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

Recently several membrane translocalizational signals (MTS) have been identified and
applied to various applications. These peptide signals, ranging between nine and 30 amino …

Cancer has become one of the leading causes of mortality globally. The major challenges of
conventional cancer therapy are the failure of most chemotherapeutic agents to accumulate …

Protein–protein interactions sequester enzymes close to their substrates. Protein kinase C
(PKC) is one example of a ubiquitous signaling molecule with effects that are dependent …

The use of various cell-penetrating peptides (CPPs) to deliver genetic material for gene
therapy applications has been a topic of interest for more than 20 years. The delivery of …

The protein transduction domain (PTD) of HIV-1 TAT has been extensively documented with
regard to its membrane transduction potential, as well as its efficient delivery of …

The human immunodeficiency virus type 1 (HIV‐1) promoter or long‐terminal repeat (LTR)
regulates viral gene expression by interacting with multiple viral and host factors. The viral …

Although not complying with Lipinski's rule, peptides are to an increasing extent being
developed into new active pharmaceutical ingredients. This is mainly due to novel …

We constructed dimeric α‐helical peptide bundles based on leucine (L) and lysine (K)
residues for both efficient cell penetration and inhibition of the Tat–TAR interaction. The LK …

Tat-derived peptides have attracted much interest as molecular carriers for intracellular
delivery as they incorporate specific attributes required for efficient cargo delivery to sub …