Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …

Interaction between tumor cells and immune cells in the tumor microenvironment is
important in cancer development. Immune cells interact with the tumor cells to shape this …

With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

Hepatocarcinogenesis involves complex genetic and cellular dysregulations which drive the
formation of hepatocellular carcinoma (HCC), the predominant form of primary liver cancer …

Background & Aims The highly proliferative nature of hepatocellular carcinoma (HCC)
frequently results in a hypoxic intratumoural microenvironment, which creates a therapeutic …

Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …

Over the last decade, precision medicine and immunotherapeutic approaches have become
increasingly popular in oncology. Early clinical trials reported promising results, but …

Unsatisfied clinical outcome drives to better understand hepatic carcinogenesis,
microenvironment and escape of immune surveillance in hepatocellular carcinoma (HCC) …