The nervous and immune systems control whole-body homeostasis and respond to various
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …

Neuroinflammation has either beneficial or detrimental effects, depending on risk factors and
neuron–glia interactions in neurological disorders. However, studying neuroinflammation …

PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate
the biology of this central nervous system (CNS)-resident myeloid population, but the …

Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) engraftment
is a promising therapy for acute ischemic stroke (AIS). However, the harsh ischemic …

Microglia are the only resident innate immune cells derived from the mesoderm in the nerve
tissue. They play a role in the development and maturation of the central nervous system …

The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Abstracts Ethnopharmacological relevance Saikosaponins B2 (SSB2) is one of the main
active components isolated from Radix Bupleuri (Bupleurum chinense DC.), a herb widely …

Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of
several chronic neurological diseases, including multiple sclerosis. Distinct metabolic and …

Central nervous system (CNS) diseases threaten the health of people all over the world.
However, due to the structural and functional particularities of the brain and spinal cord …

Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …