Industrial biocatalysis today and tomorrow

A Schmid, JS Dordick, B Hauer, A Kiener, M Wubbolts… - nature, 2001 - nature.com
The use of biocatalysis for industrial synthetic chemistry is on the verge of significant growth.
Biocatalytic processes can now be carried out in organic solvents as well as aqueous …

Pseudomonas putida—a versatile host for the production of natural products

A Loeschcke, S Thies - Applied microbiology and biotechnology, 2015 - Springer
The biosynthesis of natural products by heterologous expression of biosynthetic pathways in
amenable production strains enables biotechnological access to a variety of valuable …

Biotechnological domestication of pseudomonads using synthetic biology

PI Nikel, E Martínez-García, V De Lorenzo - Nature Reviews …, 2014 - nature.com
Much of contemporary synthetic biology research relies on the use of bacterial chassis for
plugging-in and plugging-out genetic circuits and new-to-nature functionalities. However …

Industrial methods for the production of optically active intermediates

M Breuer, K Ditrich, T Habicher, B Hauer… - Angewandte Chemie …, 2004 - Wiley Online Library
Enantiomerically pure amino acids, amino alcohols, amines, alcohols, and epoxides play an
increasingly important role as intermediates in the pharmaceutical industry and …

Engineering bacteria for bioremediation

DH Pieper, W Reineke - Current opinion in biotechnology, 2000 - Elsevier
The treatment of environmental pollution by microorganisms is a promising technology.
Various genetic approaches have been developed and used to optimize the enzymes …

Process considerations for the asymmetric synthesis of chiral amines using transaminases

P Tufvesson, J Lima‐Ramos, JS Jensen… - Biotechnology and …, 2011 - Wiley Online Library
Biocatalytic transamination is being established as key tool for the production of chiral amine
pharmaceuticals and precursors due to its excellent enantioselectivity as well as green …

Analysis of Pseudomonas putida alkane-degradation gene clusters and flanking insertion sequences: evolution and regulation of the alk genes

JB van Beilen, S Panke, S Lucchini… - …, 2001 - microbiologyresearch.org
The Pseudomonas putida GPo1 (commonly known as Pseudomonas oleovorans GPo1)
alkBFGHJKL and alkST gene clusters, which encode proteins involved in the conversion of …

Genetic tools for reliable gene expression and recombineering in Pseudomonas putida

TB Cook, JM Rand, W Nurani… - Journal of Industrial …, 2018 - academic.oup.com
Pseudomonas putida is a promising bacterial host for producing natural products, such as
polyketides and nonribosomal peptides. In these types of projects, researchers need a …

Enzymatic Oxy‐and Amino‐Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives

E Grandi, F Feyza Özgen, S Schmidt… - Angewandte …, 2023 - Wiley Online Library
Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …

Practical issues in the application of oxygenases

JB van Beilen, WA Duetz, A Schmid, B Witholt - TRENDS in Biotechnology, 2003 - cell.com
Oxygenases carry out the regio-, stereo-and chemoselective introduction of oxygen in a
tremendous range of organic molecules. This versatility has already been exploited in …