Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an
extensive formation of fibrin amyloid microclots, which are considered to contribute to the …

Platelets are one of the key mediators in thrombosis as well as in the progression of many
diseases. An increase in platelet activation and a decrease in platelet count is associated …

Current understanding of tumor immunosuppressive mechanisms forms the basis for
modern day immunotherapies. Immunoregulatory role of platelets in cancer remains largely …

Brain disorders represent a significant challenge in medical science due to the formidable
blood–brain barrier (BBB), which severely limits the penetration of conventional …

The high level of accumulation of therapeutic agents in tumors is crucial for cancer
treatment. Compared to the passive tumor-targeting effect, active tumor-targeting delivery …

Mitochondria operate as hubs of cellular metabolism that execute important regulatory
functions. Damaged/dysfunctional mitochondria are recognized as major pathogenic …

A large variety of dietary phytochemicals has been shown to improve thrombosis and stroke
outcomes in preclinical studies. Many of these compounds feature electrophilic …

Background Previous studies have shown that the relationship between high-density
lipoprotein cholesterol (HDL-C) and stroke is controversial, and the association between the …

Proteomics tools provide a powerful means to identify, detect, and quantify protein-related
details in studies of platelet phenotype and function. Here, we consider how historical and …

A multitude of laboratory and clinical interferences influence the utility of platelet-based
diagnostic indices, including immature platelet fraction, in longitudinal monitoring and …