Non-genetic factors in schizophrenia
SA Stilo, RM Murray - Current psychiatry reports, 2019 - Springer
Abstract Purpose of Review We review recent developments on risk factors in
schizophrenia. Recent Findings The way we think about schizophrenia today is profoundly …
schizophrenia. Recent Findings The way we think about schizophrenia today is profoundly …
Prenatal and perinatal risk and protective factors for psychosis: a systematic review and meta-analysis
Background Prenatal and perinatal insults are implicated in the aetiopathogenesis of
psychotic disorders but the consistency and magnitude of their associations with psychosis …
psychotic disorders but the consistency and magnitude of their associations with psychosis …
The clinical characterization of the patient with primary psychosis aimed at personalization of management
The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …
30 years on: how the neurodevelopmental hypothesis of schizophrenia morphed into the developmental risk factor model of psychosis
At its re-birth 30 years ago, the neurodevelopment hypothesis of schizophrenia focussed on
aberrant genes and early neural hazards, but then it grew to include ideas concerning …
aberrant genes and early neural hazards, but then it grew to include ideas concerning …
Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linked DNAJC6 mutations
N Wulansari, WHW Darsono, HJ Woo, MY Chang… - Science …, 2021 - science.org
Loss-of-function mutations of DNAJC6, encoding HSP40 auxilin, have recently been
identified in patients with early-onset Parkinson's disease (PD). To study the roles of …
identified in patients with early-onset Parkinson's disease (PD). To study the roles of …
[HTML][HTML] A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex
Dopamine is required for working memory, but how it modulates the large-scale cortex is
unknown. Here, we report that dopamine receptor density per neuron, measured by …
unknown. Here, we report that dopamine receptor density per neuron, measured by …
[HTML][HTML] Long-lasting effects of very preterm birth on brain structure in adulthood: A systematic review and meta-analysis
Early life experiences, such as very preterm (VP) birth, can affect brain and cognitive
development. Several prior studies investigated brain structure in adults born VP; …
development. Several prior studies investigated brain structure in adults born VP; …
Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo
L Sportelli, DP Eisenberg, R Passiatore… - Nature …, 2024 - nature.com
The polygenic architecture of schizophrenia implicates several molecular pathways involved
in synaptic function. However, it is unclear how polygenic risk funnels through these …
in synaptic function. However, it is unclear how polygenic risk funnels through these …
[HTML][HTML] Adult outcome of preterm birth: Implications for neurodevelopmental theories of psychosis
Preterm birth is associated with an elevated risk of developmental and adult psychiatric
disorders, including psychosis. In this review, we evaluate the implications of …
disorders, including psychosis. In this review, we evaluate the implications of …
Structural covariance of cortical gyrification at illness onset in treatment resistance: a longitudinal study of first-episode psychoses
Abstract Treatment resistance (TR) in patients with first-episode psychosis (FEP) is a major
cause of disability and functional impairment, yet mechanisms underlying this severe …
cause of disability and functional impairment, yet mechanisms underlying this severe …