[HTML][HTML] Anticancer therapy with HDAC inhibitors: mechanism-based combination strategies and future perspectives
R Jenke, N Reßing, FK Hansen, A Aigner, T Büch - Cancers, 2021 - mdpi.com
Simple Summary Beyond mutations, epigenetic changes have been described as drivers for
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …
[HTML][HTML] A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma
O Selim, C Song, A Kumar, R Phelan, A Singh… - Frontiers in …, 2023 - frontiersin.org
This review aims to summarize the putative role of histone deacetylases (HDACs) in
rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by …
rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by …
[HTML][HTML] Histone deacetylase expressions in hepatocellular carcinoma and functional effects of histone deacetylase inhibitors on liver cancer cells in vitro
K Freese, T Seitz, P Dietrich, SML Lee, WE Thasler… - Cancers, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is a leading cause for deaths worldwide. Histone
deacetylase (HDAC) inhibition (HDACi) is emerging as a promising therapeutic strategy …
deacetylase (HDAC) inhibition (HDACi) is emerging as a promising therapeutic strategy …
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells
E Di Bello, V Sian, G Bontempi, C Zwergel… - European Journal of …, 2023 - Elsevier
After over 30 years of research, the development of HDAC inhibitors led to five FDA/Chinese
FDA-approved drugs and many others under clinical or preclinical investigation to treat …
FDA-approved drugs and many others under clinical or preclinical investigation to treat …
Combinatorial strategies to potentiate the efficacy of HDAC inhibitors in fusion-positive sarcomas
C Lanzi, G Cassinelli - Biochemical Pharmacology, 2022 - Elsevier
Fusion positive (FP) sarcomas are characterized by chromosomal rearrangements
generating pathognomonic fusion transcripts and oncoproteins. In Ewing's sarcoma family of …
generating pathognomonic fusion transcripts and oncoproteins. In Ewing's sarcoma family of …
The PAX Genes: Roles in Development, Cancer, and Other Diseases
T Shaw, FG Barr, A Üren - Cancers, 2024 - mdpi.com
Simple Summary Humans possess a group of nine related genes that form the PAX gene
family. These genes encode proteins known as the PAX transcription factors, which control …
family. These genes encode proteins known as the PAX transcription factors, which control …
Pro-differentiating and radiosensitizing effects of inhibiting HDACs by PXD-101 (Belinostat) in in vitro and in vivo models of human rhabdomyosarcoma cell lines
F Marampon, V Di Nisio, I Pietrantoni, F Petragnano… - Cancer letters, 2019 - Elsevier
This study describes the in vitro and in vivo activity of PXD-101 (Belinostat), a novel
hydroxamic acid-type pan-HDACs inhibitor characterized by a larger safety and efficacy, on …
hydroxamic acid-type pan-HDACs inhibitor characterized by a larger safety and efficacy, on …
[HTML][HTML] MS-275 (Entinostat) promotes radio-sensitivity in PAX3-FOXO1 rhabdomyosarcoma cells
M Cassandri, S Pomella, A Rossetti… - International Journal of …, 2021 - mdpi.com
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. About
25% of RMS expresses fusion oncoproteins such as PAX3/PAX7-FOXO1 (fusion-positive …
25% of RMS expresses fusion oncoproteins such as PAX3/PAX7-FOXO1 (fusion-positive …
[HTML][HTML] Interplay between epigenetics, expression of estrogen receptor-α, HER2/ERBB2 and sensitivity of triple negative breast cancer cells to hormonal therapy
Triple negative breast cancer (TNBC) cells are resistant to hormonal/targeted therapies. This
study aims to investigate epigenetic differences between TNBC and other types of breast …
study aims to investigate epigenetic differences between TNBC and other types of breast …
[HTML][HTML] HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts
C Warnon, K Bouhjar, N Ninane, M Verhoyen… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Originally simply reported to be in a stable and irreversible growth arrest in vitro, senescent
cells are now clearly associated with normal and pathological ageing in vivo. They are …
cells are now clearly associated with normal and pathological ageing in vivo. They are …