Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure
M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …
consequences, increasing overall risk on psychopathology. One of the key stress response …
Sex differences and stress across the lifespan
TL Bale, CN Epperson - Nature neuroscience, 2015 - nature.com
Sex differences in stress responses can be found at all stages of life and are related to both
the organizational and activational effects of gonadal hormones and to genes on the sex …
the organizational and activational effects of gonadal hormones and to genes on the sex …
Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review
The early-life social environment can induce stable changes that influence
neurodevelopment and mental health. Research focused on early-life adversity revealed …
neurodevelopment and mental health. Research focused on early-life adversity revealed …
Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential
The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …
documented in humans and animal models. Even relatively brief periods of stress during the …
Epigenetic and transgenerational reprogramming of brain development
TL Bale - Nature Reviews Neuroscience, 2015 - nature.com
Neurodevelopmental programming—the implementation of the genetic and epigenetic
blueprints that guide and coordinate normal brain development—requires tight regulation of …
blueprints that guide and coordinate normal brain development—requires tight regulation of …
Toward understanding how early-life stress reprograms cognitive and emotional brain networks
Y Chen, TZ Baram - Neuropsychopharmacology, 2016 - nature.com
Vulnerability to emotional disorders including depression derives from interactions between
genes and environment, especially during sensitive developmental periods. Adverse early …
genes and environment, especially during sensitive developmental periods. Adverse early …
Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms.
Among people exposed to major psychological stressors in early life, there are elevated
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …
The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome
Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …
Neurodevelopmental optimization after early-life adversity: cross-species studies to elucidate sensitive periods and brain mechanisms to inform early intervention
Human brain development is influenced by early-life experiences, particularly during
sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the …
sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the …