Inactivation of cyclin-dependent kinase (Cdk) and reversal of Cdk phosphorylation are
universally required for mitotic exit. In budding yeast (Saccharomyces cerevisiae), Cdc14 is …

The anaphase-promoting complex, or cyclosome (APC/C), is a ubiquitin ligase that
selectively targets proteins for degradation in mitosis and the G 1 phase and is an important …

The anaphase-promoting complex/cyclosome (APC/C) is a large, multisubunit ubiquitin
ligase involved in regulation of cell division. APC/C substrate specificity arises from binding …

B-type cyclin-dependent kinase activity must be turned off for mitotic exit and G1
stabilization. B-type cyclin degradation is mediated by the anaphase-promoting …

Cell cycle arrest can be imposed by inactivating the anaphase promoting complex (APC). In
S. cerevisiae this arrest has been reported to stabilize a metaphase-like intermediate in …

The spindle assembly checkpoint (SAC), also known as the spindle or mitotic checkpoint,
arrests the metaphase-to-anaphase transition when the chromosomes are not properly …

Cell cycle transitions are driven by oscillations of cyclin-cyclin dependent kinase (CDK)
activity and associated cyclin degradation, mediated by ubiquitylation by the anaphase …

Inactivation of cyclin-dependent kinase (Cdk) and reversal of Cdk phosphorylation are
universally required for mitotic exit. In budding yeast, the protein phosphatase Cdc14 is …

Mitotic exit depends on the proper degradation of numerous cell cycle-regulated proteins,
which is executed by an E3 ubiquitin ligase called the anaphase promoting complex (APC) …