Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for
some respiratory infections. To investigate the potential for VAERD induction in coronavirus …

Animal models that can replicate clinical and pathologic features of severe human
coronavirus infections have been instrumental in the development of novel vaccines and …

The 40-year-old experience with glucocorticosteroids (GCs) in the context of severe
infections is complex and troublesome. Recently, however, a clear indication for GCs in …

Bone tissue regeneration is still a major orthopedic challenge. The process of bone
regeneration is often disrupted by inflammation. Elevated levels of reactive oxygen species …

Orally available antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) are necessary because of the continuous circulation of new variants that challenge …

Dexamethasone is a life-saving treatment for severe COVID-19, yet its mechanism of action
is unknown, and many patients deteriorate or die despite timely treatment initiation. Here, we …

Live attenuated vaccines (LAVs) administered via the mucosal route may offer better control
of the COVID-19 pandemic than non-replicating vaccines injected intramuscularly …

Background Translating findings from animal models to human disease is essential for
dissecting disease mechanisms, developing and testing precise therapeutic strategies. The …

Among the numerous long COVID symptoms, olfactory dysfunction persists in∼ 10% of
patients suffering from SARS-CoV-2 induced anosmia. Among the few potential therapies …

A key issue for research on COVID-19 pathogenesis is the lack of biopsies from patients and
of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be …