Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …

Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

In bottom-up neuroscience, questions on neural information processing are addressed by
engineering small but reproducible biological neural networks of defined network topology …

Neurodegenerative diseases, like Alzheimer's disease, Huntington's disease, Parkinson's
disease, progressive supranuclear palsy, and frontotemporal dementia are among the …

Central nervous system (CNS) drugs have had a significant impact on treating a wide range
of neurodegenerative and psychiatric disorders. In recent years, deep learning-based …

Drug optimization, which improves drug potency/specificity by structure‒activity relationship
(SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical …

Nicotinic acetylcholine receptors (nAChRs) belong to a superfamily of cys-loop receptors
characterized by the assembly of five subunits into a multi-protein channel complex. Ligand …

Autophagy is a process leading to the degradation of cellular material, in organelles called
lysosomes, to supply energy or generate building blocks for the synthesis of new materials …

Real‐world evidence (RWE) refers to observational data gathered outside the formalism of
randomized controlled trials, in real life situations, on marketed drugs. While clinical trials …

This paper investigates cognitive computation of brain metabolism in maintenance
hemodialysis patients with multimodal MRI therapy assessment. This paper constructs a …