The aggressive and recurrent nature of glioblastoma is multifactorial and has been attributed
to its biological heterogeneity, dysfunctional metabolic signaling pathways, rigid blood–brain …

Background Glioblastoma is the most common malignant brain tumor in human adults.
Despite several improvements in resective as well as adjuvant therapy over the last …

Colorectal cancer (CRC) has a poor prognosis and urgently needs better therapeutic
approaches. 5-Aminolevulinic acid (ALA) induced protoporphyrin IX (PpIX) based …

OBJECTIVE Only one phase III prospective randomized study, published in 2006, has
assessed the performance of 5-aminolevulinic acid (5-ALA) fluorescence–guided surgery …

Background Intraoperative pathologic diagnosis traditionally involves frozen section
histopathology, which may be labor and time intensive. Indeed, a technique that streamlines …

Gliomas are the most common primary malignant tumors of the central nervous system, and
their conventional treatment involves maximal safe surgical resection combined with …

Simple Summary In the era of targeted therapies, achieving a maximal safe resection still
remains a critical prognosis factor in diffuse low-grade gliomas and represents the goal to …

Simple Summary Current literature debates the development and implementation of three-
dimensional Exoscopes in the daily routine of neurosurgical practice. This study evaluates …

Optical coherence tomography (OCT) of the ex vivo rat and human brain tissue samples is
performed. The set of samples comprises intact white and gray matter, as well as human …

Objective Due to the infiltrative nature and high local recurrence of gliomas, particularly high-
grade gliomas, gross total resection (GTR) of a tumor is the first critical step in treatment. This …