Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered …

The gastric mucosa maintains structural integrity and function despite continuous exposure
to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue …

The resolution of the inflammatory response is highly regulated by the timely biosynthesis of
a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers …

Lipoxins (LXs) or the lipoxygenase interaction products are generated from arachidonic acid
via sequential actions of lipoxygenases and subsequent reactions to give specific …

Background & Aims: It has been variably suggested that nonselective NSAIDs and
cyclooxygenase (COX)-2 selective inhibitors aggravate or ameliorate clinical disease activity …

Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) are some of the most
prescribed drugs worldwide and have now probably overtaken Helicobacter pylori as the …

Background and purpose: Hydrogen sulphide is an important mediator of gastric mucosal
defence. The use of non‐steroidal anti‐inflammatory drugs continues to be limited by their …

Background & Aims: Gastrointestinal damage caused by nonsteroidal anti-inflammatory
drugs (NSAIDs) remains a significant clinical problem. Hydrogen makes an important …

Surfactants are a diverse group of compounds that share the capacity to adsorb at the
boundary between distinct phases of matter. They are used as pharmaceutical excipients …

The established model for the mechanism of action of aspirin is the inhibition of
prostaglandin synthesis. However, this has never fully explained aspirin's repertoire of …