Lipogenesis inhibitors: therapeutic opportunities and challenges
B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
[HTML][HTML] Lipid metabolism and cancer
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
Acetyl-CoA carboxylases and diseases
Y Wang, W Yu, S Li, D Guo, J He, Y Wang - Frontiers in oncology, 2022 - frontiersin.org
Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to
meet the biosynthetic demands of a growing tumor. This process is controlled by the rate …
meet the biosynthetic demands of a growing tumor. This process is controlled by the rate …
Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens
Late-stage functionalization of natural products offers an elegant route to create novel
entities in a relevant biological target space. In this context, enzymes capable of …
entities in a relevant biological target space. In this context, enzymes capable of …
Natural products from myxobacteria: novel metabolites and bioactivities
J Herrmann, A Abou Fayad, R Müller - Natural product reports, 2017 - pubs.rsc.org
Covering: 2011–July 2016 Myxobacteria are a rich source for structurally diverse secondary
metabolites with intriguing biological activities. Here we report on new natural products that …
metabolites with intriguing biological activities. Here we report on new natural products that …
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats
G Harriman, J Greenwood, S Bhat… - Proceedings of the …, 2016 - National Acad Sciences
Simultaneous inhibition of the acetyl-CoA carboxylase (ACC) isozymes ACC1 and ACC2
results in concomitant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation …
results in concomitant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation …
Structural basis for regulation of human acetyl-CoA carboxylase
M Hunkeler, A Hagmann, E Stuttfeld, M Chami, Y Guri… - Nature, 2018 - nature.com
Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-
limiting step in fatty acid biosynthesis,. Eukaryotic acetyl-CoA carboxylases are large …
limiting step in fatty acid biosynthesis,. Eukaryotic acetyl-CoA carboxylases are large …
AMPK signaling and its targeting in cancer progression and treatment
The intrinsic mechanisms sensing the imbalance of energy in cells are pivotal for cell
survival under various environmental insults. AMP-activated protein kinase (AMPK) serves …
survival under various environmental insults. AMP-activated protein kinase (AMPK) serves …
Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase
Human acetyl–coenzyme A (CoA) carboxylases (ACCs) catalyze the carboxylation of acetyl-
CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism …
CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism …