Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Abstract miR-124 is a miRNA predominantly expressed in the nervous system and accounts
for more than a quarter of the total miRNAs in the brain. It regulates neurogenesis, neuronal …

Epigenetic alterations are a fundamental pathological hallmark of Alzheimer's disease (AD).
Herein, we show the upregulation of G9a and H3K9me2 in the brains of AD patients …

The establishment and maintenance of neuronal polarity are important for neural
development and function. Abnormal neuronal polarity establishment commonly leads to a …

The Corpus Callosum (CC) is a bundle of axons connecting the cerebral hemispheres. It is
the most recent structure to have appeared during evolution of placental mammals. Its …

Cellular metabolism plays an essential role in the regrowth and regeneration of a neuron
following physical injury. Yet, our knowledge of the specific metabolic pathways that are …

The establishment of polarity is crucial for the physiology and wiring of neurons. Therefore,
monitoring the axo-dendritic specification allows the mechanisms and signals associated …

Stroke, also known as cerebral stroke or cerebrovascular accident, refers to acute ischemic
or hemorrhagic encephalopathy caused by a disturbance to cerebral blood flow. Ischemic …

Mechanical stimulation is the key physical factor in cell environment. Mechanotransduction
acts as a fundamental regulator of cell behavior, regulating cell proliferation, differentiation …

ABSTRACT G9a, also known as EHMT2, is essential for embryogenesis and has specific
functions in multiple developmental processes. G9a inactivation affects development of the …