Highlights•Peptide diversification by posttranslational modification of precursor
proteins.•Genome mining functionally diverse protein superfamilies yields RiPP …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
family of natural products with diverse activities and structures. RiPP classes are defined by …

Darobactin is a heptapeptide antibiotic featuring an ether cross-link and a C–C cross-link,
and both cross-links are installed by a radical S-adenosylmethionine (rSAM) enzyme DarE …

Ribosomally synthesized and post‐translationally modified peptides (RiPPs) are a
fascinating group of natural products that exhibit diverse structural features and bioactivities …

Antibiotic resistance is a huge public health security crisis around the world. Darobactin is a
ribosomally produced and post-translationally modified heptapeptide antibiotic with a …

Cyclic peptide natural products represent an important class of bioactive compounds and
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …

DUF692 multinuclear iron oxygenases (MNIOs) are an emerging family of tailoring enzymes
involved in the biosynthesis of ribosomally synthesized and post-translationally modified …

Advancements in DNA sequencing technologies and bioinformatics have enabled the
discovery of new metabolic reactions from overlooked microbial species and metagenomic …

Advances in genome sequencing and bioinformatics methods have identified a myriad of
biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining …

Cyclic peptides with cyclophane linkers are an attractive compound type owing to the fine‐
tuned rigid three‐dimensional structures and unusual biophysical features. Cytochrome …