Clinical management of metastatic colorectal cancer in the era of precision medicine

F Ciardiello, D Ciardiello, G Martini… - CA: a cancer journal …, 2022 - Wiley Online Library
Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …

Diagnosis and treatment of metastatic colorectal cancer: a review

LH Biller, D Schrag - Jama, 2021 - jamanetwork.com
Importance Colorectal cancer (CRC) is the third most common cause of cancer mortality
worldwide with more than 1.85 million cases and 850 000 deaths annually. Of new …

Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a …

LA Diaz, KK Shiu, TW Kim, BV Jensen… - The Lancet …, 2022 - thelancet.com
Background Pembrolizumab has shown improved progression-free survival versus
chemotherapy in patients with newly diagnosed microsatellite instability-high or mismatch …

[HTML][HTML] Treatment of metastatic colorectal cancer: ASCO guideline

VK Morris, EB Kennedy, NN Baxter… - Journal of clinical …, 2023 - ncbi.nlm.nih.gov
Treatment of Metastatic Colorectal Cancer: ASCO Guideline - PMC Back to Top Skip to main
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …

Colorectal liver metastasis: molecular mechanism and interventional therapy

H Zhou, Z Liu, Y Wang, X Wen, EH Amador… - Signal transduction and …, 2022 - nature.com
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Colon cancer, version 2.2021, NCCN clinical practice guidelines in oncology

AB Benson, AP Venook, MM Al-Hawary… - Journal of the National …, 2021 - jnccn.org
This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)
for Colon Cancer focuses on systemic therapy options for the treatment of metastatic …

Young-onset colorectal cancer

MCW Spaander, AG Zauber, S Syngal… - Nature Reviews …, 2023 - nature.com
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Comprehensive review of targeted therapy for colorectal cancer

YH Xie, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Panitumumab vs bevacizumab added to standard first-line chemotherapy and overall survival among patients with RAS wild-type, left-sided metastatic colorectal …

J Watanabe, K Muro, K Shitara, K Yamazaki… - JAMA, 2023 - jamanetwork.com
Importance For patients withRASwild-type metastatic colorectal cancer, adding anti–
epidermal growth factor receptor (anti-EGFR) or anti–vascular endothelial growth factor (anti …

Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements

A Malki, RA ElRuz, I Gupta, A Allouch, S Vranic… - International journal of …, 2020 - mdpi.com
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …