Obesity: global epidemiology and pathogenesis

M Blüher - Nature Reviews Endocrinology, 2019 - nature.com
The prevalence of obesity has increased worldwide in the past~ 50 years, reaching
pandemic levels. Obesity represents a major health challenge because it substantially …

Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

[HTML][HTML] Environmental influences on the epigenome: exposure-associated DNA methylation in human populations

EM Martin, RC Fry - Annual review of public health, 2018 - annualreviews.org
DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …

[HTML][HTML] Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility

C Gundacker, M Forsthuber, T Szigeti, R Kakucs… - International Journal of …, 2021 - Elsevier
Lead (Pb) is a ubiquitous environmental pollutant and a potent toxic compound. Humans are
exposed to Pb through inhalation, ingestion, and skin contact via food, water, tobacco …

The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility

C De Angelis, M Galdiero, C Pivonello, C Salzano… - Reproductive …, 2017 - Elsevier
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly
susceptible to cadmium, and testis injury occurs at high but even low levels of exposure …

[HTML][HTML] Molecular mechanisms underlying neuroinflammation elicited by occupational injuries and toxicants

D Pathak, K Sriram - International Journal of Molecular Sciences, 2023 - mdpi.com
Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

[HTML][HTML] How air pollution alters brain development: the role of neuroinflammation

S Brockmeyer, A d'Angiulli - Translational neuroscience, 2016 - degruyter.com
The present review synthesizes lines of emerging evidence showing how several samples
of children populations living in large cities around the world suffer to some degree neural …

[HTML][HTML] Volatile organic compounds: a proinflammatory activator in autoimmune diseases

JO Ogbodo, AV Arazu, TC Iguh, NJ Onwodi… - Frontiers in …, 2022 - frontiersin.org
The etiopathogenesis of inflammatory and autoimmune diseases, including pulmonary
disease, atherosclerosis, and rheumatoid arthritis, has been linked to human exposure to …

Ecotoxic pharmaceuticals, personal care products, and other emerging contaminants: A review of environmental, receptor-mediated, developmental, and epigenetic …

JL Wilkinson, PS Hooda, J Barker… - Critical Reviews in …, 2016 - Taylor & Francis
Pharmaceuticals and personal care products (PPCPs), other emerging contaminants (ECs),
and metabolites thereof are ubiquitous in the environment, both built and natural. While such …

Heavy metals, cardiovascular disease, and the unexpected benefits of chelation therapy

GA Lamas, A Navas-Acien, DB Mark, KL Lee - Journal of the American …, 2016 - jacc.org
This review summarizes evidence from 2 lines of research previously thought to be
unrelated: the unexpectedly positive results of TACT (Trial to Assess Chelation Therapy) …