Neuroblastoma (NB) is one of the most common pediatric malignancies. Easy metastasis,
poor prognosis, and a high degree of heterogeneity of NB hinder its successful treatment …

Simple Summary Epigenetic alterations contribute to the distinct biology of pancreatic ductal
adenocarcinoma (PDAC) and thus allow a better understanding of molecular mechanisms …

The biological roles of DNA methylation have been elucidated by profiling methods based
on whole-genome or reduced-representation bisulfite sequencing, but these approaches do …

How bone marrow niches regulate leukemogenic activities of leukemia-initiating cells (LICs)
is unclear. The present study revealed that the metabolic niche component, ATP, efficiently …

This study explores the contributions of neutrophils to chemotherapeutic resistance and
berberine-regulated cancer cell sensitivity to doxorubicin (DOX). In vitro experiments …

Neutrophils are innate immune cells that are key to protecting the host against infection and
maintaining body homeostasis. However, if dysregulated, they can contribute to disease …

MYB plays vital roles in regulating proliferation and differentiation of hematopoietic
progenitor cells, dysregulation of MYB has been implicated in the pathogenesis of leukemia …

Epigenetic marks do not change the sequence of DNA but affect gene expression in a cell-
type specific manner by altering the activities of regulatory elements. Development of new …

Cancer cell lines often have large structural variants (SVs) that evolve over time. There are
many reported differences in large scale SVs between HL-60 and HL-60/S4, two cell lines …

The severity of COVID-19 is linked to excessive inflammation. Neutrophils represent a
critical arm of the innate immune response and are major mediators of inflammation, but …