Feature selection methods in QSAR studies
M Goodarzi, B Dejaegher… - Journal of AOAC …, 2012 - academic.oup.com
A quantitative structure-activity relationship (QSAR) relates quantitative chemical structure
attributes (molecular descriptors) to a biological activity. QSAR studies have now become …
attributes (molecular descriptors) to a biological activity. QSAR studies have now become …
3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis
The 3-ketoacyl-ACP synthase (KAS) III proteins are one of the most abundant enzymes in
nature, as they are involved in the biosynthesis of fatty acids and natural products. KAS III …
nature, as they are involved in the biosynthesis of fatty acids and natural products. KAS III …
Design, synthesis, and structure–activity relationships of pyrazole derivatives as potential FabH inhibitors
PC Lv, J Sun, Y Luo, Y Yang, HL Zhu - Bioorganic & medicinal chemistry …, 2010 - Elsevier
Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors
PC Lv, KR Wang, Y Yang, WJ Mao, J Chen… - Bioorganic & medicinal …, 2009 - Elsevier
Fatty acid biosynthesis is essential for bacterial survival. Components of this biosynthetic
pathway have been identified as attractive targets for the development of new antibacterial …
pathway have been identified as attractive targets for the development of new antibacterial …
Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1, 2, 3, 4 …
SK Sharma, P Kumar, B Narasimhan… - European journal of …, 2012 - Elsevier
A series of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,
2, 3, 4-tetrahydropyrimidine-5-carboxylic acid ethyl esters (1–16) were synthesized and …
2, 3, 4-tetrahydropyrimidine-5-carboxylic acid ethyl esters (1–16) were synthesized and …
Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
XL Wang, YB Zhang, JF Tang, YS Yang… - European journal of …, 2012 - Elsevier
Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N′-phenyl-thiourea
HJ Zhang, X Qin, K Liu, DD Zhu, XM Wang… - Bioorganic & medicinal …, 2011 - Elsevier
A series of novel Schiff base derivatives have been designed and synthesized, and their
biological activities were also evaluated as potential inhibitors of FabH. These compounds …
biological activities were also evaluated as potential inhibitors of FabH. These compounds …
Discovery of novel selective inhibitors of Staphylococcus aureus β-ketoacyl acyl carrier protein synthase III
JY Lee, KW Jeong, S Shin, JU Lee, Y Kim - European journal of medicinal …, 2012 - Elsevier
β-Ketoacyl-acyl carrier protein synthase III (KAS III) is a condensing enzyme in bacterial fatty
acid synthesis and a potential target while designing novel antibiotics. In our previous report …
acid synthesis and a potential target while designing novel antibiotics. In our previous report …
Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N2-acyl isonicotinic acid hydrazide derivatives
A series of N2-acyl isonicotinic acid hydrazides (1-17) was synthesized and tested for its in
vitro antimycobacterial activity against Mycobacterium tuberculosis and the results indicated …
vitro antimycobacterial activity against Mycobacterium tuberculosis and the results indicated …
Thiolactomycin-based β-Ketoacyl-AcpM Synthase A (KasA) Inhibitors [S]
K Kapilashrami, GR Bommineni, CA Machutta… - Journal of Biological …, 2013 - ASBMB
Thiolactomycin (TLM) is a natural product inhibitor of KasA, the β-ketoacyl synthase A from
Mycobacterium tuberculosis. To improve the affinity of TLM for KasA, a series of TLM …
Mycobacterium tuberculosis. To improve the affinity of TLM for KasA, a series of TLM …