Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation
genes more than two decades ago, their protein products have been implicated in a variety …

The mammalian BTG/Tob family comprises six proteins (BTG1, BTG2/PC3/Tis21,
BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2), which regulate cell cycle progression in a …

Altered expression of microRNA (miRNA) is strongly implicated in cancer, and recent studies
have shown that, in cancer, expression of some miRNAs cells is silenced in association with …

The importance of the p53 protein in the cellular response to DNA damage is well known,
but its function during steady-state hematopoiesis has not been established. We have …

Little is known about the regulation and function of the Notch1 gene in negative control of
human tumors. Here we show that Notch1 gene expression and activity are substantially …

The incidence and mortality of hepatocellular carcinoma (HCC) have fallen dramatically in
China and elsewhere over the past several decades. Nonetheless, HCC remains a major …

How higher organisms respond to elevated oxidative stress in vivo is poorly understood.
Therefore, we measured oxidative stress parameters and gene expression alterations …

Background & Aims There has not been a broad analysis of the combined effects of altered
activities of microRNAs (miRNAs) in pancreatic ductal adenocarcinoma (PDAC) cells, and it …

Three decades of p53 research have led to many advances in understanding the basic
biology of normal and cancer cells. Nonetheless, the detailed functions of p53 in normal …

Abstract Since the mid-1950's, melanoma incidence has been rising steadily in
industrialized Caucasian populations, thereby pointing to the pivotal involvement of …