The rapidly aging population desperately requires new therapies for Alzheimer's disease.
Despite years of pharmaceutical research, limited clinical success has been realized, with …

Alzheimer's disease (AD) is the most common form of progressive neurodegenerative
disorder, marked by memory loss and a decline in cognitive function. The major hallmarks of …

Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

Sequential proteolysis of the amyloid precursor protein (APP) by γ‐secretases generates
amyloid‐β (Aβ) peptides and defines the proportion of short‐to‐long Aβ peptides, which is …

Presenilin (PSEN) pathogenic mutations cause familial Alzheimer's disease (AD [FAD]) in an
autosomal-dominant manner. The extent to which the healthy and diseased alleles influence …

Abstract γ‐Secretase complexes (GSEC s) are multimeric membrane proteases involved in
a variety of physiological processes and linked to Alzheimer's disease (AD). Presenilin …

People with Down's syndrome (DS) are at high risk for developing Alzheimer's disease (AD)
at a relatively young age. This increased risk is not observed in people with intellectual …

C-Amino-1, 2, 4-triazoles are challenging polynitrogen substrates for metal-catalyzed
arylation due to their multidentate character, enhanced coordinating ability and decreased …

Alzheimer's disease (AD) pathogenesis has been linked to the accumulation of longer,
aggregation‐prone amyloid β (Aβ) peptides in the brain. Γ‐secretases generate Aβ peptides …

Background: The treatment and diagnosis of Alzheimer's Disease (AD) are two of the most
urgent goals for research around the world. The cognitive decline is generally associated …