Midostaurin: a novel therapeutic agent for patients with FLT3-mutated acute myeloid leukemia and systemic mastocytosis
MM Gallogly, HM Lazarus… - Therapeutic advances in …, 2017 - journals.sagepub.com
The development of FLT3-targeted inhibitors represents an important paradigm shift in the
management of patients with highly aggressive fms-like tyrosine kinase 3-mutated (FLT3 …
management of patients with highly aggressive fms-like tyrosine kinase 3-mutated (FLT3 …
[HTML][HTML] Reprogramming acute myeloid leukemia into sensitivity for retinoic-acid-driven differentiation
The success of all-trans retinoic acid (ATRA) therapy for acute promyelocytic leukemia (APL)
provides a rationale for using retinoic acid (RA)-based therapy for other subtypes of acute …
provides a rationale for using retinoic acid (RA)-based therapy for other subtypes of acute …
All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo
HS Ma, SM Greenblatt, CM Shirley… - Blood, The Journal …, 2016 - ashpublications.org
FMS-like tyrosine kinase 3 (FLT3)-mutant acute myeloid leukemia (AML) portends a poor
prognosis, and ineffective targeting of the leukemic stem cell (LSC) population remains one …
prognosis, and ineffective targeting of the leukemic stem cell (LSC) population remains one …
Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3
H Lu, X Weng, Y Sheng, J Wu, H Xi, X Cai - BMC cancer, 2022 - Springer
Background Midostaurin combined with chemotherapy is currently used to treat newly
diagnosed acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 (FLT3) …
diagnosed acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 (FLT3) …
Arsenic trioxide and all-trans-retinoic acid selectively exert synergistic cytotoxicity against FLT3-ITD AML cells via co-inhibition of FLT3 signaling pathways
LN Wang, YL Tang, YC Zhang, ZH Zhang… - Leukemia & …, 2017 - Taylor & Francis
FLT3-ITD mutations occur in approximately 30% of acute myeloid leukemia (AML) and are
associated with a poor outcome. Currently available FLT3 inhibitors have in vitro but limited …
associated with a poor outcome. Currently available FLT3 inhibitors have in vitro but limited …
[HTML][HTML] 去泛素化酶UCHL3 维持FLT3-ITD 阳性急性髓性白血病细胞存活的功能研究
胡家诚， 朱倩， 王佳琦， 吴英理… - 上海交通大学学报(医学 …, 2022 - xuebao.shsmu.edu.cn
目的· 探究FMS 样的酪氨酸激酶3 (FMS-like tyrosine kinase 3, FLT3) 近膜区的内部串联重复(
FLT3-ITD) 阳性急性髓系白血病(acute myeloid leukemia, AML) 细胞中存在表达差异的去泛素 …
FLT3-ITD) 阳性急性髓系白血病(acute myeloid leukemia, AML) 细胞中存在表达差异的去泛素 …
Combined effect of (‑)‑epigallocatechin‑3‑gallate and all‑trans retinoic acid in FLT3‑mutated cell lines
Patents diagnosed with acute promyelocytic leukemia were treated with Vesanoid®[all‑trans
retinoic acid (ATRA)]. ATRA promotes the maturation and differentiation of leukemia cells …
retinoic acid (ATRA)]. ATRA promotes the maturation and differentiation of leukemia cells …
Potential Role for All-trans Retinoic Acid in Nonpromyelocytic Acute Myeloid Leukemia
HS Ma, TM Robinson, D Small - International Journal of …, 2016 - Taylor & Francis
All-trans retinoic acid (ATRA) has been very successful in the subtype of acute myelogenous
leukemia known as acute promyelocytic leukemia due to targeted reactivation of retinoic …
leukemia known as acute promyelocytic leukemia due to targeted reactivation of retinoic …
Function of UCHL3 in maintaining the survival of FLT3-ITD positive acute myeloid leukemia cells
HU Jiacheng, ZHU Qian, W Jiaqi… - Journal of Shanghai …, 2022 - xuebao.shsmu.edu.cn
Objective· To explore differently expressed deubiquitinases in acute myeloid leukemia
(AML) cells with internal tandem duplications of the FLT3 (FLT3-ITD) gene mutation …
(AML) cells with internal tandem duplications of the FLT3 (FLT3-ITD) gene mutation …
ction of UCHL3 in maintaining the survival of FLT3-ITD positive acute myeloid leukemia c
HU Jiacheng, ZHU Qian, W Jiaqi… - Journal of Shanghai … - xuebao.shsmu.edu.cn
Objective· To explore differently expressed deubiquitinases in acute myeloid leukemia
(AML) cells with internal tandem duplications of the FLT3 (FLT3-ITD) gene mutation …
(AML) cells with internal tandem duplications of the FLT3 (FLT3-ITD) gene mutation …