Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
The use and popularity of herbal medicines has been increasing worldwide. In fact, today,
the traditional Chinese medicine offers a vast repertory for pharmaceutical research, as is …
the traditional Chinese medicine offers a vast repertory for pharmaceutical research, as is …
A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides
CM Wilhelm, TH Snider, MC Babin, DA Jett… - Toxicology and applied …, 2014 - Elsevier
The currently fielded pre-hospital therapeutic regimen for the treatment of
organophosphorus (OP) poisoning in the United States (US) is the administration of atropine …
organophosphorus (OP) poisoning in the United States (US) is the administration of atropine …
Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor
YJ Rosenberg, L Mao, X Jiang, J Lees, L Zhang… - Chemico-biological …, 2017 - Elsevier
Organophosphate (OP) nerve agents and pesticides trigger a common mechanism of
neurotoxicity resulting from critical targeting and inhibition of acetylcholinesterases (AChE) …
neurotoxicity resulting from critical targeting and inhibition of acetylcholinesterases (AChE) …
The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs
Organophosphorus-based (OP) nerve agents represent some of the most toxic substances
known to mankind. The current standard of care for exposure has changed very little in the …
known to mankind. The current standard of care for exposure has changed very little in the …
A novel genetically modified mouse seizure model for evaluating anticonvulsive and neuroprotective efficacy of an A1 adenosine receptor agonist following soman …
TM Shih - Toxicology and applied pharmacology, 2023 - Elsevier
Recently a novel humanized mouse strain has been successfully generated, in which serum
carboxylesterase (CES) knock out (KO) mice (Es1−/−) were further genetically modified by …
carboxylesterase (CES) knock out (KO) mice (Es1−/−) were further genetically modified by …
Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1, 3, 2-benzodioxaphosphorin-2-oxide (CBDP)
G Horn, S Rappenglück, F Worek - Toxicology Letters, 2024 - Elsevier
The aerotoxic syndrome has been associated with exposure to tricresyl phosphate (TCP),
which is used as additive in hydraulic fluids and engine lubricants. The toxic metabolite 2-(2 …
which is used as additive in hydraulic fluids and engine lubricants. The toxic metabolite 2-(2 …
Characterization of Humanized Mouse Model of Organophosphate Poisoning and Detection of Countermeasures via MALDI-MSI
CM Tressler, B Wadsworth, S Carriero… - International Journal of …, 2024 - mdpi.com
Organophosphoate (OP) chemicals are known to inhibit the enzyme acetylcholinesterase
(AChE). Studying OP poisoning is difficult because common small animal research models …
(AChE). Studying OP poisoning is difficult because common small animal research models …
In vivo efficacy of the Reactive Skin Decontamination Lotion (RSDL®) kit against organophosphate and carbamate pesticides
M Fentabil, M Gebremedhin, J Barry, J Mikler… - Chemico-Biological …, 2020 - Elsevier
In this study, we assessed the efficacy of the Reactive Skin Decontamination Lotion
(RSDL®) Kit against parathion and aldicarb pesticide dermal exposure in a guinea pig …
(RSDL®) Kit against parathion and aldicarb pesticide dermal exposure in a guinea pig …
Efficacy of the oxime HI-6 dimethanesulphonate in the treatment of guinea-pigs exposed to the nerve agents GB and GD
H Rice, SJ Whitfield, SJ Fairhall, IR Scott… - Toxicology Letters, 2024 - Elsevier
The bispyridinium oxime HI-6 DMS is in development as an improved therapy for the
treatment of patients exposed to organophosphorus nerve agents. The aim of the work …
treatment of patients exposed to organophosphorus nerve agents. The aim of the work …
Evaluating the broad-spectrum efficacy of the acetylcholinesterase oximes reactivators MMB4 DMS, HLö-7 DMS, and 2-PAM Cl against phorate oxon, sarin, and VX in …
CM Wilhelm, TH Snider, MC Babin, GE Platoff Jr… - Neurotoxicology, 2018 - Elsevier
Organophosphorus (OP) compounds, including pesticides and chemical warfare nerve
agents (CWNA), are threats to the general population as possible weapons of terrorism or by …
agents (CWNA), are threats to the general population as possible weapons of terrorism or by …