The multidisciplinary fields of tissue engineering and regenerative medicine have the
potential to revolutionize the practise of medicine through the abilities to repair, regenerate …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

The matrix metalloproteinases (MMPs), a family of 25 secreted and cell surface-bound
neutral proteinases, process a large array of extracellular and cell surface proteins under …

The basement membrane (BM), a specialized network of extracellular matrix
macromolecules, surrounds epithelial, endothelial, muscle, fat and nerve cells. During …

The epidermis functions in skin as first defense line or barrier against environmental
impacts, resting on extracellular matrix (ECM) of the dermis underneath. Both compartments …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Proteases are crucial for development, tissue remodeling, and tumorigenesis. Matrix
metalloproteinases (MMPs) family, in particular, consists of more than 20 members with …