Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

DX Tan, LC Manchester, X Liu… - Journal of pineal …, 2013 - Wiley Online Library
Mitochondria and chloroplasts are major sources of free radical generation in living
organisms. Because of this, these organelles require strong protection from free radicals and …

Therapeutic potential of melatonin related to its role as an autophagy regulator: A review

JA Boga, B Caballero, Y Potes… - Journal of pineal …, 2019 - Wiley Online Library
There are several pathologies, syndromes, and physiological processes in which autophagy
is involved. This process of self‐digestion that cells trigger as a survival mechanism is …

Melatonin alleviates inflammasome‐induced pyroptosis through inhibiting NF‐κB/GSDMD signal in mice adipose tissue

Z Liu, L Gan, Y Xu, D Luo, Q Ren… - Journal of Pineal …, 2017 - Wiley Online Library
Pyroptosis is a proinflammatory form of cell death that is associated with pathogenesis of
many chronic inflammatory diseases. Melatonin is substantially reported to possess anti …

Arabidopsis transcriptome analysis reveals key roles of melatonin in plant defense systems

S Weeda, N Zhang, X Zhao, G Ndip, Y Guo, GA Buck… - PloS one, 2014 - journals.plos.org
Melatonin is a ubiquitous molecule and exists across kingdoms including plant species.
Studies on melatonin in plants have mainly focused on its physiological influence on growth …

Markers of oxidant stress that are clinically relevant in aging and age-related disease

KD Jacob, NN Hooten, AR Trzeciak… - Mechanisms of ageing and …, 2013 - Elsevier
Despite the long held hypothesis that oxidant stress results in accumulated oxidative
damage to cellular macromolecules and subsequently to aging and age-related chronic …

Measurement of anthocyanins and other phytochemicals in purple wheat

FS Hosseinian, W Li, T Beta - Food Chemistry, 2008 - Elsevier
The major anthocyanin composition of normal purple wheat and heat stressed purple wheat
were measured using HPLC, LC–MS/MS and the pH differential method. The lignan …

Physiological melatonin levels in healthy older people: A systematic review

RM Scholtens, BC van Munster, MF van Kempen… - Journal of …, 2016 - Elsevier
Objective Melatonin plays a major role in maintaining circadian rhythm. Previous studies
showed that its secretion pattern and levels could be disturbed in persons with dementia …

Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity

K Szewczyk‐Golec, A Woźniak… - Journal of pineal …, 2015 - Wiley Online Library
Obesity and its medical complications represent a significant problem throughout the world.
In recent decades, mechanisms underlying the progression of obesity have been intensively …

Oxidative stress and immunosenescence: therapeutic effects of melatonin

J Espino, JA Pariente… - Oxidative Medicine and …, 2012 - Wiley Online Library
Age‐associated deterioration in the immune system, which is referred to as
immunosenescence, contributes to an increased susceptibility to infectious diseases …

Effects of increasing tryptophan intake on growth and physiological changes in nursery pigs

YB Shen, G Voilqué, JD Kim, J Odle… - Journal of animal …, 2012 - academic.oup.com
Tryptophan (Trp) as a precursor of serotonin (5-hydroxytryptamine, 5-HT) has long been
used to extenuate aggressive behavior and control stress of humans as well as several farm …